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Daily Health News Roundup - Updated: 2025-12-24

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HEALTH FLASH - December 24, 2025

Headline: Short therapeutic peptide CAQK shows brain‑trauma protection in animals and moves toward human trials — a potential fast path to limiting long‑term neurodegeneration after injury.

TOP 3 STORIES:
1. CAQK peptide reduces inflammation, cell death and improves recovery after traumatic brain injury in mice and pigs; developer Aivocode plans FDA permission-seeking for Phase I trials — a small, easily manufactured peptide that homes to injured brain tissue could become the first acute therapy to limit post‑traumatic neurodegeneration and chronic cognitive decline if human results replicate animal benefits[1]. Practical implication: for biohackers and clinicians this points to a near‑term therapeutic class (short homing peptides) that could be integrated into emergency/acute care pathways to protect brain health after concussive events and reduce later dementia risk[1]. [Source: ScienceDaily / Sanford Burnham Prebys press coverage][1]

2. Harvard teams propose lithium’s normal presence in brain protects against neurodegeneration and a novel lithium compound restored memory in mouse models — this reframes lithium from a mood stabilizer to a potential preventive/therapeutic agent for Alzheimer’s disease and other neurodegenerative disorders[2]. Practical implication: monitoring lithium status and metabolism may become a measurable biomarker for brain resilience, while targeted lithium formulations or microdosing strategies could enter precision prevention protocols pending human trials[2]. [Source: Harvard Medical School summary][2]

3. Broad 2025 momentum: AI diagnostics, regenerative biologics (exosomes/peptides), microglial and metabolic Alzheimer approaches, and expanded peptide/exosome therapeutics reshaped translational pipelines — 2025 saw validation of prevention pathways for Alzheimer’s, advances in regenerative biologics and faster AI‑driven diagnostics that together lower the barrier from discovery to clinic[4][1]. Practical implication: longevity optimizers should expect faster translation of targeted biologics and AI‑guided personalized interventions (e.g., earlier biomarker detection, tailored peptide/regenerative treatments), making regular advanced screening and data‑driven personalization increasingly valuable[4][1].

Flash Insight: 2025’s signal is consolidation — small, targeted biologics (short peptides, exosomes) and precision diagnostics (AI‑enabled genomics/biomarkers) are converging to make acute neuroprotection and tailored prevention realistic within a few years[1][2][4]. For longevity enthusiasts, that means prioritizing actionable biomarkers (metabolic, inflammatory, neurochemical) and integrating rapid‑response plans (trauma protocols, access to clinical trials) could materially affect long-term brain health. Expect increased opportunities to participate in early trials and to use AI/precision tools for optimization as regulatory pathways adapt.

Sources and links
[1] ScienceDaily — This tiny peptide could help stop brain damage after injury — https://www.sciencedaily.com/releases/2025/12/251223084538.htm

[2] Harvard Medical School — Harvard Medical School's Top Science News of 2025 (lithium and Alzheimer’s coverage) — https://hms.harvard.edu/news/harvard-medical-schools-top-science-news-2025

[4] World Economic Forum — The top global health stories from 2025 — https://www.weforum.org/stories/2025/12/the-top-global-health-stories-from-2025/

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